Malegra DXT Plus is a combination medication that typically contains Sildenafil Citrate (for erectile dysfunction) and Duloxetine (for premature ejaculation). Malegra DXT Plus works primarily on the blood vessels by inhibiting the enzyme PDE5 (phosphodiesterase type 5). This inhibition allows levels of cGMP to remain higher in the smooth muscle cells lining blood vessels, especially in the penis. As a result, blood vessels relax and dilate, increasing blood flow to the erectile tissues. This vasodilation effect is what helps men achieve and maintain erections. While Sildenafil mainly targets penile blood vessels, it can also cause dilation in other parts of the body, sometimes leading to side effects like flushing, nasal congestion, dizziness, or mild blood pressure drops. Duloxetine, on the other hand, does not directly act on blood vessels but works on the nervous system to delay ejaculation. Together, Malegra DXT Plus improves sexual function by enhancing erection quality and controlling ejaculation.
